Drug interactions
Buprenorphine + Eribulin
Severity: Moderate
Buprenorphine and Eribulin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eribulin can prolong the QT interval, and buprenorphine may add to this. Torsades de pointes risk is higher with electrolyte abnormalities or heart failure.
What this interaction means in plain words
Buprenorphine and Eribulin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Buprenorphine belongs to Musculoskeletal; Eribulin belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Obtain an ECG before starting and periodically thereafter, and correct hypokalemia and hypomagnesemia. Consider a different analgesic if the QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Buprenorphine
- Alvimopan + Buprenorphine Contraindicated
- Buprenorphine + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Buprenorphine + Olanzapine / samidorphan Contraindicated
- Buprenorphine + Phenelzine Contraindicated
- Buprenorphine + Pimozide Contraindicated
- Buprenorphine + Thioridazine Contraindicated
Other interactions of Eribulin
Frequently asked questions
Can I take Buprenorphine with Eribulin?
MediHelp rates the interaction as moderate. Buprenorphine and Eribulin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eribulin can prolong the QT interval, and buprenorphine may add to this. Torsades de pointes risk is higher with electrolyte abnormalities or heart failure.
How serious is the interaction between Buprenorphine and Eribulin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG before starting and periodically thereafter, and correct hypokalemia and hypomagnesemia. Consider a different analgesic if the QTc becomes markedly prolonged.
What other medicines interact with Buprenorphine?
MediHelp also lists interactions of Buprenorphine with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan. The full list is on the Buprenorphine page.
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