Drug interactions
Buprenorphine + Etrasimod
Severity: Moderate
Buprenorphine and Etrasimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etrasimod can transiently slow heart rate and conduction on initiation, and buprenorphine can prolong the QT interval at higher doses. The combination may increase arrhythmia risk in susceptible patients.
What this interaction means in plain words
Buprenorphine and Etrasimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Buprenorphine belongs to Musculoskeletal; Etrasimod belongs to Gastrointestinal Tract.
Why it happens
Additive bradycardic and QT-prolonging effects.
What to do
Obtain a baseline ECG in patients with risk factors and monitor heart rate and QTc during etrasimod initiation. Correct electrolyte abnormalities and avoid other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Buprenorphine
- Alvimopan + Buprenorphine Contraindicated
- Buprenorphine + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Buprenorphine + Olanzapine / samidorphan Contraindicated
- Buprenorphine + Phenelzine Contraindicated
- Buprenorphine + Pimozide Contraindicated
- Buprenorphine + Thioridazine Contraindicated
Other interactions of Etrasimod
- Abatacept + Etrasimod Major
- Amiodarone + Etrasimod Major
- Anagrelide + Etrasimod Major
- Anakinra + Etrasimod Major
- Anti-thymocyte + Etrasimod Major
- Asenapine + Etrasimod Major
Frequently asked questions
Can I take Buprenorphine with Etrasimod?
MediHelp rates the interaction as moderate. Buprenorphine and Etrasimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etrasimod can transiently slow heart rate and conduction on initiation, and buprenorphine can prolong the QT interval at higher doses. The combination may increase arrhythmia risk in susceptible patients.
How serious is the interaction between Buprenorphine and Etrasimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG in patients with risk factors and monitor heart rate and QTc during etrasimod initiation. Correct electrolyte abnormalities and avoid other QT-prolonging drugs.
What other medicines interact with Buprenorphine?
MediHelp also lists interactions of Buprenorphine with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan. The full list is on the Buprenorphine page.
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