Drug interactions
Buprenorphine + Istradefylline
Severity: Minor
Buprenorphine and Istradefylline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At higher doses, istradefylline weakly inhibits CYP3A4 and may increase exposure to CYP3A4 substrates such as buprenorphine. The effect is likely small at the 20 mg daily dose.
What this interaction means in plain words
Buprenorphine and Istradefylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Buprenorphine belongs to Musculoskeletal; Istradefylline belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4 by istradefylline reduces buprenorphine metabolism.
What to do
Monitor for increased opioid effects such as sedation, and consider reducing the buprenorphine dose if istradefylline 40 mg daily is used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Buprenorphine
- Alvimopan + Buprenorphine Contraindicated
- Buprenorphine + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Buprenorphine + Olanzapine / samidorphan Contraindicated
- Buprenorphine + Phenelzine Contraindicated
- Buprenorphine + Pimozide Contraindicated
- Buprenorphine + Thioridazine Contraindicated
Other interactions of Istradefylline
Frequently asked questions
Can I take Buprenorphine with Istradefylline?
MediHelp rates the interaction as minor. Buprenorphine and Istradefylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. At higher doses, istradefylline weakly inhibits CYP3A4 and may increase exposure to CYP3A4 substrates such as buprenorphine. The effect is likely small at the 20 mg daily dose.
How serious is the interaction between Buprenorphine and Istradefylline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased opioid effects such as sedation, and consider reducing the buprenorphine dose if istradefylline 40 mg daily is used.
What other medicines interact with Buprenorphine?
MediHelp also lists interactions of Buprenorphine with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan. The full list is on the Buprenorphine page.
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