Drug interactions
Buprenorphine + Ivosidenib
Severity: Moderate
Buprenorphine and Ivosidenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib induces CYP3A4 and may lower buprenorphine concentrations, risking reduced analgesia or opioid withdrawal. Ivosidenib also prolongs QT, so combined use may add some arrhythmia risk.
What this interaction means in plain words
Buprenorphine and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Buprenorphine belongs to Musculoskeletal; Ivosidenib belongs to Oncology.
Why it happens
CYP3A4 induction by ivosidenib lowers buprenorphine exposure, plus additive QTc prolongation.
What to do
Monitor for withdrawal symptoms or loss of analgesic effect and adjust the buprenorphine dose. Check ECG and electrolytes during combination.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Buprenorphine
- Alvimopan + Buprenorphine Contraindicated
- Buprenorphine + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Buprenorphine + Olanzapine / samidorphan Contraindicated
- Buprenorphine + Phenelzine Contraindicated
- Buprenorphine + Pimozide Contraindicated
- Buprenorphine + Thioridazine Contraindicated
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Buprenorphine with Ivosidenib?
MediHelp rates the interaction as moderate. Buprenorphine and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivosidenib induces CYP3A4 and may lower buprenorphine concentrations, risking reduced analgesia or opioid withdrawal. Ivosidenib also prolongs QT, so combined use may add some arrhythmia risk.
How serious is the interaction between Buprenorphine and Ivosidenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for withdrawal symptoms or loss of analgesic effect and adjust the buprenorphine dose. Check ECG and electrolytes during combination.
What other medicines interact with Buprenorphine?
MediHelp also lists interactions of Buprenorphine with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan. The full list is on the Buprenorphine page.
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