Drug interactions
Buprenorphine + Larotrectinib
Severity: Minor
Buprenorphine and Larotrectinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is a CYP3A4 substrate and may weakly inhibit it, so buprenorphine levels could rise slightly. The expected clinical effect is small, with possible added sedation.
What this interaction means in plain words
Buprenorphine and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Buprenorphine belongs to Musculoskeletal; Larotrectinib belongs to Oncology.
Why it happens
Possible weak CYP3A4 inhibition by larotrectinib reducing buprenorphine clearance.
What to do
Monitor for sedation and respiratory depression when the combination is started. Adjust buprenorphine only if signs of excess opioid effect appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Buprenorphine
- Alvimopan + Buprenorphine Contraindicated
- Buprenorphine + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Buprenorphine + Olanzapine / samidorphan Contraindicated
- Buprenorphine + Phenelzine Contraindicated
- Buprenorphine + Pimozide Contraindicated
- Buprenorphine + Thioridazine Contraindicated
Other interactions of Larotrectinib
Frequently asked questions
Can I take Buprenorphine with Larotrectinib?
MediHelp rates the interaction as minor. Buprenorphine and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib is a CYP3A4 substrate and may weakly inhibit it, so buprenorphine levels could rise slightly. The expected clinical effect is small, with possible added sedation.
How serious is the interaction between Buprenorphine and Larotrectinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and respiratory depression when the combination is started. Adjust buprenorphine only if signs of excess opioid effect appear.
What other medicines interact with Buprenorphine?
MediHelp also lists interactions of Buprenorphine with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan. The full list is on the Buprenorphine page.
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