Drug interactions
Buprenorphine + Lidocaine
Severity: Minor
Buprenorphine and Lidocaine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic lidocaine can cause sedation and may add to opioid CNS depression, though clinically significant interaction is uncommon at usual doses. Topical or local use carries negligible risk.
What this interaction means in plain words
Buprenorphine and Lidocaine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Buprenorphine belongs to Musculoskeletal; Lidocaine belongs to Cardiovascular.
Why it happens
Possible additive CNS depression from systemic lidocaine.
What to do
With intravenous lidocaine, monitor sedation and respiratory status. No action is needed for local or topical use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Buprenorphine
- Alvimopan + Buprenorphine Contraindicated
- Buprenorphine + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Buprenorphine + Olanzapine / samidorphan Contraindicated
- Buprenorphine + Phenelzine Contraindicated
- Buprenorphine + Pimozide Contraindicated
- Buprenorphine + Thioridazine Contraindicated
Other interactions of Lidocaine
- Bupivacaine liposome + Lidocaine Major
- Disopyramide + Lidocaine Major
- Ex vivo expanded autologous human corneal epithelial cells containing stem cells + Lidocaine Major
- Lidocaine + Nirmatrelvir / ritonavir Major
- Lidocaine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Lidocaine + Pimozide Major
Frequently asked questions
Can I take Buprenorphine with Lidocaine?
MediHelp rates the interaction as minor. Buprenorphine and Lidocaine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Systemic lidocaine can cause sedation and may add to opioid CNS depression, though clinically significant interaction is uncommon at usual doses. Topical or local use carries negligible risk.
How serious is the interaction between Buprenorphine and Lidocaine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: With intravenous lidocaine, monitor sedation and respiratory status. No action is needed for local or topical use.
What other medicines interact with Buprenorphine?
MediHelp also lists interactions of Buprenorphine with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan. The full list is on the Buprenorphine page.
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