Drug interactions
Buprenorphine + Pazopanib
Severity: Major
Buprenorphine and Pazopanib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pazopanib is labeled with a warning for QT prolongation and torsades de pointes, and buprenorphine may add to this risk. Pazopanib may also inhibit CYP3A4 weakly.
What this interaction means in plain words
Buprenorphine and Pazopanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Buprenorphine belongs to Musculoskeletal; Pazopanib belongs to Oncology.
Why it happens
Additive QT prolongation, with possible minor CYP3A4 inhibition.
What to do
Check baseline and periodic ECGs and electrolytes, and avoid other QT-prolonging drugs. Consider an alternative analgesic if the QTc rises significantly.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Buprenorphine
- Alvimopan + Buprenorphine Contraindicated
- Buprenorphine + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Buprenorphine + Olanzapine / samidorphan Contraindicated
- Buprenorphine + Phenelzine Contraindicated
- Buprenorphine + Pimozide Contraindicated
- Buprenorphine + Thioridazine Contraindicated
Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Buprenorphine with Pazopanib?
MediHelp rates the interaction as major. Buprenorphine and Pazopanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pazopanib is labeled with a warning for QT prolongation and torsades de pointes, and buprenorphine may add to this risk. Pazopanib may also inhibit CYP3A4 weakly.
How serious is the interaction between Buprenorphine and Pazopanib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline and periodic ECGs and electrolytes, and avoid other QT-prolonging drugs. Consider an alternative analgesic if the QTc rises significantly.
What other medicines interact with Buprenorphine?
MediHelp also lists interactions of Buprenorphine with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan. The full list is on the Buprenorphine page.
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