Drug interactions
Buprenorphine buccal + Cyclobenzaprine
Severity: Major
Buprenorphine buccal and Cyclobenzaprine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a sedating muscle relaxant with buprenorphine increases the risk of profound sedation, respiratory depression, coma and death. The risk is greatest at higher doses and in opioid-naive or frail patients.
What this interaction means in plain words
Buprenorphine buccal and Cyclobenzaprine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression.
What to do
Use only if no alternative exists, with the lowest effective doses and shortest duration. Monitor for sedation and slowed breathing.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Buprenorphine buccal and Cyclobenzaprine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
References
Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Buprenorphine buccal with Cyclobenzaprine?
MediHelp rates the interaction as major. Buprenorphine buccal and Cyclobenzaprine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining a sedating muscle relaxant with buprenorphine increases the risk of profound sedation, respiratory depression, coma and death. The risk is greatest at higher doses and in opioid-naive or frail patients.
How serious is the interaction between Buprenorphine buccal and Cyclobenzaprine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only if no alternative exists, with the lowest effective doses and shortest duration. Monitor for sedation and slowed breathing.
What other medicines interact with Cyclobenzaprine?
MediHelp also lists interactions of Cyclobenzaprine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Cyclobenzaprine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
