Drug interactions
Buprenorphine buccal + Eribulin
Severity: Moderate
Buprenorphine buccal and Eribulin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Buprenorphine has been associated with dose-related QT prolongation, and eribulin can also prolong the QT interval. Co-use may add to arrhythmia risk, mainly in patients with other risk factors.
What this interaction means in plain words
Buprenorphine buccal and Eribulin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic effect on cardiac repolarization (QT prolongation).
What to do
Check a baseline ECG and electrolytes, then monitor the QTc during combined use. Consider a lower buprenorphine dose or alternative if QTc rises significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eribulin
Frequently asked questions
Can I take Buprenorphine buccal with Eribulin?
MediHelp rates the interaction as moderate. Buprenorphine buccal and Eribulin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Buprenorphine has been associated with dose-related QT prolongation, and eribulin can also prolong the QT interval. Co-use may add to arrhythmia risk, mainly in patients with other risk factors.
How serious is the interaction between Buprenorphine buccal and Eribulin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and electrolytes, then monitor the QTc during combined use. Consider a lower buprenorphine dose or alternative if QTc rises significantly.
What other medicines interact with Eribulin?
MediHelp also lists interactions of Eribulin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Eribulin page.
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