Drug interactions
Buprenorphine buccal + Lidocaine
Severity: Minor
Buprenorphine buccal and Lidocaine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic lidocaine can add to the sedative and respiratory depressant effects of buprenorphine. The effect is mostly relevant with intravenous lidocaine infusion. Local anesthetic use usually has negligible impact.
What this interaction means in plain words
Buprenorphine buccal and Lidocaine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive CNS and respiratory depression.
What to do
When systemic lidocaine is used, monitor sedation level and respiratory rate. No change is needed for local infiltration.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lidocaine
- Bupivacaine liposome + Lidocaine Major
- Disopyramide + Lidocaine Major
- Ex vivo expanded autologous human corneal epithelial cells containing stem cells + Lidocaine Major
- Lidocaine + Nirmatrelvir / ritonavir Major
- Lidocaine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Lidocaine + Pimozide Major
Frequently asked questions
Can I take Buprenorphine buccal with Lidocaine?
MediHelp rates the interaction as minor. Buprenorphine buccal and Lidocaine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Systemic lidocaine can add to the sedative and respiratory depressant effects of buprenorphine. The effect is mostly relevant with intravenous lidocaine infusion. Local anesthetic use usually has negligible impact.
How serious is the interaction between Buprenorphine buccal and Lidocaine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: When systemic lidocaine is used, monitor sedation level and respiratory rate. No change is needed for local infiltration.
What other medicines interact with Lidocaine?
MediHelp also lists interactions of Lidocaine with, for example, Bupivacaine liposome, Disopyramide, Ex vivo expanded autologous human corneal epithelial cells containing stem cells. The full list is on the Lidocaine page.
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