Drug interactions
Buprenorphine buccal + Nilotinib
Severity: Major
Buprenorphine buccal and Nilotinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QTc interval, raising the risk of arrhythmia. Buccal buprenorphine delivers systemic doses relevant to QT effect.
What this interaction means in plain words
Buprenorphine buccal and Nilotinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QTc prolongation; nilotinib may also raise buprenorphine via CYP3A4 inhibition.
What to do
Obtain a baseline ECG and monitor it, and correct electrolytes. Consider alternatives if QTc is prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Buprenorphine buccal with Nilotinib?
MediHelp rates the interaction as major. Buprenorphine buccal and Nilotinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QTc interval, raising the risk of arrhythmia. Buccal buprenorphine delivers systemic doses relevant to QT effect.
How serious is the interaction between Buprenorphine buccal and Nilotinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor it, and correct electrolytes. Consider alternatives if QTc is prolonged.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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