Drug interactions
Buprenorphine buccal + Oxcarbazepine
Severity: Moderate
Buprenorphine buccal and Oxcarbazepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxcarbazepine may reduce buprenorphine concentrations through CYP3A4 induction. This could cause reduced analgesia or opioid withdrawal symptoms.
What this interaction means in plain words
Buprenorphine buccal and Oxcarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of CYP3A4 increases buprenorphine N-dealkylation.
What to do
Monitor for withdrawal symptoms or inadequate pain control and titrate buprenorphine as needed. Reassess the dose if oxcarbazepine is started or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Oxcarbazepine Major
- Atazanavir + Oxcarbazepine Major
- Benzhydrocodone / acetaminophen + Oxcarbazepine Major
- Bictegravir + Oxcarbazepine Major
Frequently asked questions
Can I take Buprenorphine buccal with Oxcarbazepine?
MediHelp rates the interaction as moderate. Buprenorphine buccal and Oxcarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxcarbazepine may reduce buprenorphine concentrations through CYP3A4 induction. This could cause reduced analgesia or opioid withdrawal symptoms.
How serious is the interaction between Buprenorphine buccal and Oxcarbazepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for withdrawal symptoms or inadequate pain control and titrate buprenorphine as needed. Reassess the dose if oxcarbazepine is started or stopped.
What other medicines interact with Oxcarbazepine?
MediHelp also lists interactions of Oxcarbazepine with, for example, Cabotegravir, Rilpivirine, Artemether / lumefantrine. The full list is on the Oxcarbazepine page.
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