Drug interactions
Buprenorphine buccal + Rasagiline
Severity: Major
Buprenorphine buccal and Rasagiline: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids with MAO inhibitors can lead to additive CNS and respiratory depression, hypotension, or serotonin-like reactions. Buprenorphine has a partial agonist profile but the caution still applies.
What this interaction means in plain words
Buprenorphine buccal and Rasagiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS depression and possible serotonergic effects with MAO inhibition; not fully defined.
What to do
Avoid concurrent use where possible and monitor sedation, respiration, temperature and blood pressure if both are needed. Use the lowest effective buprenorphine dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Frequently asked questions
Can I take Buprenorphine buccal with Rasagiline?
MediHelp rates the interaction as major. Buprenorphine buccal and Rasagiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Opioids with MAO inhibitors can lead to additive CNS and respiratory depression, hypotension, or serotonin-like reactions. Buprenorphine has a partial agonist profile but the caution still applies.
How serious is the interaction between Buprenorphine buccal and Rasagiline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible and monitor sedation, respiration, temperature and blood pressure if both are needed. Use the lowest effective buprenorphine dose.
What other medicines interact with Rasagiline?
MediHelp also lists interactions of Rasagiline with, for example, Atomoxetine, Brimonidine, Bupropion-naltrexone. The full list is on the Rasagiline page.
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