Drug interactions
Buprenorphine buccal + Sunitinib
Severity: Moderate
Buprenorphine buccal and Sunitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Buprenorphine can prolong QT at higher doses, and sunitinib also prolongs QT. The additive effect raises arrhythmia risk, particularly in patients with other risk factors.
What this interaction means in plain words
Buprenorphine buccal and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation.
What to do
Obtain a baseline ECG and monitor electrolytes and QTc, using the lowest effective buprenorphine dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sunitinib
- Adagrasib + Sunitinib Major
- Amiodarone + Sunitinib Major
- Amisulpride + Sunitinib Major
- Anagrelide + Sunitinib Major
- Apalutamide + Sunitinib Major
- Arsenic trioxide + Sunitinib Major
Frequently asked questions
Can I take Buprenorphine buccal with Sunitinib?
MediHelp rates the interaction as moderate. Buprenorphine buccal and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Buprenorphine can prolong QT at higher doses, and sunitinib also prolongs QT. The additive effect raises arrhythmia risk, particularly in patients with other risk factors.
How serious is the interaction between Buprenorphine buccal and Sunitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor electrolytes and QTc, using the lowest effective buprenorphine dose.
What other medicines interact with Sunitinib?
MediHelp also lists interactions of Sunitinib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sunitinib page.
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