Drug interactions
Buprenorphine buccal + Telavancin
Severity: Moderate
Buprenorphine buccal and Telavancin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Telavancin has been associated with modest QT interval prolongation, and buprenorphine can also lengthen the QT interval. Used together, the effects may be additive and raise the risk of torsades de pointes, particularly with other risk factors.
What this interaction means in plain words
Buprenorphine buccal and Telavancin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic QT prolongation through effects on cardiac repolarization.
What to do
Obtain a baseline ECG and correct potassium and magnesium before combining. Monitor the QTc during therapy, and choose an alternative agent in patients with congenital long QT or other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Telavancin
- Telavancin + Thioridazine Contraindicated
- Adagrasib + Telavancin Major
- Amiodarone + Telavancin Major
- Amisulpride + Telavancin Major
- Anagrelide + Telavancin Major
- Arsenic trioxide + Telavancin Major
Frequently asked questions
Can I take Buprenorphine buccal with Telavancin?
MediHelp rates the interaction as moderate. Buprenorphine buccal and Telavancin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Telavancin has been associated with modest QT interval prolongation, and buprenorphine can also lengthen the QT interval. Used together, the effects may be additive and raise the risk of torsades de pointes, particularly with other risk factors.
How serious is the interaction between Buprenorphine buccal and Telavancin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium before combining. Monitor the QTc during therapy, and choose an alternative agent in patients with congenital long QT or other QT-prolonging drugs.
What other medicines interact with Telavancin?
MediHelp also lists interactions of Telavancin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Telavancin page.
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