Drug interactions
Buprenorphine long-acting + Cyclosporin
Severity: Moderate
Buprenorphine long-acting and Cyclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine may increase systemic buprenorphine from long-acting injection by inhibiting CYP3A4. Because the depot cannot be quickly adjusted, excess opioid effects such as sedation and respiratory depression may persist.
What this interaction means in plain words
Buprenorphine long-acting and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated buprenorphine metabolism by cyclosporine.
What to do
Monitor for sedation, respiratory depression and signs of toxicity, especially in the first weeks after starting either drug. If toxicity occurs and cyclosporine cannot be stopped, move to a transmucosal buprenorphine formulation that allows dose adjustment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Frequently asked questions
Can I take Buprenorphine long-acting with Cyclosporin?
MediHelp rates the interaction as moderate. Buprenorphine long-acting and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine may increase systemic buprenorphine from long-acting injection by inhibiting CYP3A4. Because the depot cannot be quickly adjusted, excess opioid effects such as sedation and respiratory depression may persist.
How serious is the interaction between Buprenorphine long-acting and Cyclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, respiratory depression and signs of toxicity, especially in the first weeks after starting either drug. If toxicity occurs and cyclosporine cannot be stopped, move to a transmucosal buprenorphine formulation that allows dose adjustment.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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