Drug interactions
Buprenorphine long-acting + Dimenhydrinate
Severity: Moderate
Buprenorphine long-acting and Dimenhydrinate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
A sedating antihistamine can increase drowsiness and potentially respiratory depression with buprenorphine. The long-acting injection cannot be withdrawn quickly, so effects may be prolonged.
What this interaction means in plain words
Buprenorphine long-acting and Dimenhydrinate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS and respiratory depression.
What to do
Monitor for sedation and slowed breathing, and minimize other sedating drugs. Counsel patients to avoid alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dimenhydrinate
Frequently asked questions
Can I take Buprenorphine long-acting with Dimenhydrinate?
MediHelp rates the interaction as moderate. Buprenorphine long-acting and Dimenhydrinate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. A sedating antihistamine can increase drowsiness and potentially respiratory depression with buprenorphine. The long-acting injection cannot be withdrawn quickly, so effects may be prolonged.
How serious is the interaction between Buprenorphine long-acting and Dimenhydrinate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and slowed breathing, and minimize other sedating drugs. Counsel patients to avoid alcohol.
What other medicines interact with Dimenhydrinate?
MediHelp also lists interactions of Dimenhydrinate with, for example, Belladonna and opium, Brexanolone, Calcium / magnesium / potassium / sodium oxybates. The full list is on the Dimenhydrinate page.
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