Drug interactions
Buprenorphine long-acting + Eprosartan-hydrochlorothiazide
Severity: Minor
Buprenorphine long-acting and Eprosartan-hydrochlorothiazide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids can stimulate antidiuretic hormone release and cause fluid retention, which may blunt diuretic effect. Opioids may also add to hypotension, especially with volume depletion from a thiazide.
What this interaction means in plain words
Buprenorphine long-acting and Eprosartan-hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opioid-induced ADH release may antagonize diuresis, with additive hypotensive effects.
What to do
Monitor blood pressure, fluid status and electrolytes; adjust antihypertensive or diuretic dosing if control changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Buprenorphine long-acting with Eprosartan-hydrochlorothiazide?
MediHelp rates the interaction as minor. Buprenorphine long-acting and Eprosartan-hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Opioids can stimulate antidiuretic hormone release and cause fluid retention, which may blunt diuretic effect. Opioids may also add to hypotension, especially with volume depletion from a thiazide.
How serious is the interaction between Buprenorphine long-acting and Eprosartan-hydrochlorothiazide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, fluid status and electrolytes; adjust antihypertensive or diuretic dosing if control changes.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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