Drug interactions
Buprenorphine long-acting + Isocarboxazid
Severity: Contraindicated
Buprenorphine long-acting and Isocarboxazid: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids with serotonergic activity combined with MAOIs can cause serotonin syndrome, and MAOIs may also potentiate opioid toxicity including respiratory depression and coma. Labeling advises against long-acting buprenorphine in patients on MAOIs or within 14 days of stopping.
What this interaction means in plain words
Buprenorphine long-acting and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Excess serotonergic activity plus MAOI-related potentiation of opioid CNS and respiratory depression.
What to do
Do not use long-acting buprenorphine during or within 14 days after MAOI therapy. Choose an alternative treatment.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicated
- Amitriptyline + Isocarboxazid Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amoxapine + Isocarboxazid Contraindicated
- Apraclonidine + Isocarboxazid Contraindicated
- Atomoxetine + Isocarboxazid Contraindicated
Frequently asked questions
Can I take Buprenorphine long-acting with Isocarboxazid?
MediHelp rates the interaction as contraindicated. Buprenorphine long-acting and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Opioids with serotonergic activity combined with MAOIs can cause serotonin syndrome, and MAOIs may also potentiate opioid toxicity including respiratory depression and coma. Labeling advises against long-acting buprenorphine in patients on MAOIs or within 14 days of stopping.
How serious is the interaction between Buprenorphine long-acting and Isocarboxazid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use long-acting buprenorphine during or within 14 days after MAOI therapy. Choose an alternative treatment.
What other medicines interact with Isocarboxazid?
MediHelp also lists interactions of Isocarboxazid with, for example, 5-HTP, Amitriptyline, Amobarbital. The full list is on the Isocarboxazid page.
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