Drug interactions
Buprenorphine long-acting + Nilotinib
Severity: Moderate
Buprenorphine long-acting and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QTc interval, so combined use increases arrhythmia risk. The long-acting injection cannot be quickly withdrawn if problems arise.
What this interaction means in plain words
Buprenorphine long-acting and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QTc prolongation; possible CYP3A4 inhibition by nilotinib.
What to do
Obtain a baseline ECG and monitor QTc and electrolytes periodically. Reassess the regimen if QTc lengthens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Buprenorphine long-acting with Nilotinib?
MediHelp rates the interaction as moderate. Buprenorphine long-acting and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QTc interval, so combined use increases arrhythmia risk. The long-acting injection cannot be quickly withdrawn if problems arise.
How serious is the interaction between Buprenorphine long-acting and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc and electrolytes periodically. Reassess the regimen if QTc lengthens.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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