Drug interactions
Buprenorphine long-acting + Oxcarbazepine
Severity: Moderate
Buprenorphine long-acting and Oxcarbazepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxcarbazepine may lower buprenorphine plasma concentrations from the long-acting injection. Reduced exposure may cause withdrawal symptoms or inadequate treatment of opioid use disorder.
What this interaction means in plain words
Buprenorphine long-acting and Oxcarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 induction by oxcarbazepine increases buprenorphine clearance.
What to do
Monitor for withdrawal symptoms and cravings. If exposure proves inadequate, switch to a buprenorphine formulation that permits dose adjustment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Oxcarbazepine Major
- Atazanavir + Oxcarbazepine Major
- Benzhydrocodone / acetaminophen + Oxcarbazepine Major
- Bictegravir + Oxcarbazepine Major
Frequently asked questions
Can I take Buprenorphine long-acting with Oxcarbazepine?
MediHelp rates the interaction as moderate. Buprenorphine long-acting and Oxcarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxcarbazepine may lower buprenorphine plasma concentrations from the long-acting injection. Reduced exposure may cause withdrawal symptoms or inadequate treatment of opioid use disorder.
How serious is the interaction between Buprenorphine long-acting and Oxcarbazepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for withdrawal symptoms and cravings. If exposure proves inadequate, switch to a buprenorphine formulation that permits dose adjustment.
What other medicines interact with Oxcarbazepine?
MediHelp also lists interactions of Oxcarbazepine with, for example, Cabotegravir, Rilpivirine, Artemether / lumefantrine. The full list is on the Oxcarbazepine page.
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