Drug interactions
Buprenorphine long-acting + Spironolactone
Severity: Minor
Buprenorphine long-acting and Spironolactone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids can stimulate antidiuretic hormone release and cause fluid retention, which may blunt the diuretic effect of spironolactone. The effect is usually modest but can matter in patients treated for heart failure or ascites.
What this interaction means in plain words
Buprenorphine long-acting and Spironolactone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opioid-induced antidiuretic hormone release opposes diuretic-mediated water and sodium loss (pharmacodynamic antagonism).
What to do
Monitor weight, edema and fluid balance, and increase the diuretic dose if response declines.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Spironolactone
- Amiloride + Spironolactone Contraindicated
- Eplerenone + Spironolactone Contraindicated
- Spironolactone + Triamterene Contraindicated
- Abiraterone + Spironolactone Major
- Aceclofenac + Spironolactone Major
- Acemetacin + Spironolactone Major
Frequently asked questions
Can I take Buprenorphine long-acting with Spironolactone?
MediHelp rates the interaction as minor. Buprenorphine long-acting and Spironolactone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Opioids can stimulate antidiuretic hormone release and cause fluid retention, which may blunt the diuretic effect of spironolactone. The effect is usually modest but can matter in patients treated for heart failure or ascites.
How serious is the interaction between Buprenorphine long-acting and Spironolactone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor weight, edema and fluid balance, and increase the diuretic dose if response declines.
What other medicines interact with Spironolactone?
MediHelp also lists interactions of Spironolactone with, for example, Amiloride, Eplerenone, Triamterene. The full list is on the Spironolactone page.
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