Drug interactions
Buprenorphine long-acting + Sunitinib
Severity: Moderate
Buprenorphine long-acting and Sunitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Long-acting buprenorphine injection may prolong QT and sunitinib shares this effect, potentially increasing arrhythmia risk. Exposure from the depot persists for weeks.
What this interaction means in plain words
Buprenorphine long-acting and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation.
What to do
Obtain baseline and periodic ECGs and correct electrolytes, especially in patients with cardiac risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sunitinib
- Adagrasib + Sunitinib Major
- Amiodarone + Sunitinib Major
- Amisulpride + Sunitinib Major
- Anagrelide + Sunitinib Major
- Apalutamide + Sunitinib Major
- Arsenic trioxide + Sunitinib Major
Frequently asked questions
Can I take Buprenorphine long-acting with Sunitinib?
MediHelp rates the interaction as moderate. Buprenorphine long-acting and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Long-acting buprenorphine injection may prolong QT and sunitinib shares this effect, potentially increasing arrhythmia risk. Exposure from the depot persists for weeks.
How serious is the interaction between Buprenorphine long-acting and Sunitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain baseline and periodic ECGs and correct electrolytes, especially in patients with cardiac risk factors.
What other medicines interact with Sunitinib?
MediHelp also lists interactions of Sunitinib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sunitinib page.
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