Drug interactions
Buprenorphine long-acting + Triamterene
Severity: Minor
Buprenorphine long-acting and Triamterene: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids can promote antidiuretic hormone release, causing fluid retention that opposes diuretic effect. Opioids may also add to hypotension in volume-depleted patients, but with buprenorphine the clinical impact is likely small.
What this interaction means in plain words
Buprenorphine long-acting and Triamterene have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opioid-related ADH release may reduce diuretic efficacy, and opioids can add to orthostatic hypotension.
What to do
Monitor fluid status, weight and blood pressure; adjust the diuretic dose if response is reduced.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Triamterene
- Amiloride + Triamterene Contraindicated
- Eplerenone + Triamterene Contraindicated
- Potassium citrate / citric acid + Triamterene Contraindicated
- Potassium citrate + Triamterene Contraindicated
- Spironolactone + Triamterene Contraindicated
- Aceclofenac + Triamterene Major
Frequently asked questions
Can I take Buprenorphine long-acting with Triamterene?
MediHelp rates the interaction as minor. Buprenorphine long-acting and Triamterene have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Opioids can promote antidiuretic hormone release, causing fluid retention that opposes diuretic effect. Opioids may also add to hypotension in volume-depleted patients, but with buprenorphine the clinical impact is likely small.
How serious is the interaction between Buprenorphine long-acting and Triamterene?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fluid status, weight and blood pressure; adjust the diuretic dose if response is reduced.
What other medicines interact with Triamterene?
MediHelp also lists interactions of Triamterene with, for example, Amiloride, Eplerenone, Potassium citrate / citric acid. The full list is on the Triamterene page.
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