Drug interactions
Buprenorphine subdermal implant + Nilotinib
Severity: Moderate
Buprenorphine subdermal implant and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QTc interval, so combined use increases arrhythmia risk. Nilotinib may also raise buprenorphine concentrations.
What this interaction means in plain words
Buprenorphine subdermal implant and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QTc prolongation; nilotinib may inhibit CYP3A4 metabolism of buprenorphine.
What to do
Obtain baseline and periodic ECGs and correct electrolytes. Reassess if QTc lengthens or symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Buprenorphine subdermal implant with Nilotinib?
MediHelp rates the interaction as moderate. Buprenorphine subdermal implant and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QTc interval, so combined use increases arrhythmia risk. Nilotinib may also raise buprenorphine concentrations.
How serious is the interaction between Buprenorphine subdermal implant and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain baseline and periodic ECGs and correct electrolytes. Reassess if QTc lengthens or symptoms occur.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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