Drug interactions
Buprenorphine subdermal implant + Paroxetine
Severity: Minor
Buprenorphine subdermal implant and Paroxetine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Buprenorphine has a minor QT effect, and paroxetine has little, so additive QT risk is small. Serotonergic and CNS depressant effects are also possible but uncommon with buprenorphine.
What this interaction means in plain words
Buprenorphine subdermal implant and Paroxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible small additive effects on QT and serotonergic activity.
What to do
No change is routinely needed. Monitor for sedation and serotonin toxicity features, and check ECG in patients with long QT or other risk factors.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Buprenorphine subdermal implant with Paroxetine?
MediHelp rates the interaction as minor. Buprenorphine subdermal implant and Paroxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Buprenorphine has a minor QT effect, and paroxetine has little, so additive QT risk is small. Serotonergic and CNS depressant effects are also possible but uncommon with buprenorphine.
How serious is the interaction between Buprenorphine subdermal implant and Paroxetine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No change is routinely needed. Monitor for sedation and serotonin toxicity features, and check ECG in patients with long QT or other risk factors.
What other medicines interact with Paroxetine?
MediHelp also lists interactions of Paroxetine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Paroxetine page.
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