Drug interactions
Buprenorphine subdermal implant + Rasagiline
Severity: Major
Buprenorphine subdermal implant and Rasagiline: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids with serotonergic activity, including buprenorphine, can contribute to serotonin syndrome when combined with MAO inhibitors. Opioids also carry a risk of CNS and respiratory depression in this context.
What this interaction means in plain words
Buprenorphine subdermal implant and Rasagiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive serotonergic effects of MAO inhibition and buprenorphine.
What to do
Avoid the combination if possible, otherwise monitor closely for serotonin toxicity, especially at initiation and dose changes. Remove the implant and treat if serotonin syndrome is suspected.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Frequently asked questions
Can I take Buprenorphine subdermal implant with Rasagiline?
MediHelp rates the interaction as major. Buprenorphine subdermal implant and Rasagiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Opioids with serotonergic activity, including buprenorphine, can contribute to serotonin syndrome when combined with MAO inhibitors. Opioids also carry a risk of CNS and respiratory depression in this context.
How serious is the interaction between Buprenorphine subdermal implant and Rasagiline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible, otherwise monitor closely for serotonin toxicity, especially at initiation and dose changes. Remove the implant and treat if serotonin syndrome is suspected.
What other medicines interact with Rasagiline?
MediHelp also lists interactions of Rasagiline with, for example, Atomoxetine, Brimonidine, Bupropion-naltrexone. The full list is on the Rasagiline page.
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