Drug interactions
Buprenorphine subdermal implant + Safinamide
Severity: Major
Buprenorphine subdermal implant and Safinamide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Buprenorphine has serotonergic activity and co-use with MAO inhibitors may cause serotonin syndrome or opioid toxicity. Risk is greater at initiation and dose changes.
What this interaction means in plain words
Buprenorphine subdermal implant and Safinamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive serotonergic effects with MAO-B inhibition and possible potentiation of opioid effects.
What to do
Avoid if possible. If used, monitor for agitation, tremor, hyperthermia and sedation, and remove the implant and treat if serotonin syndrome occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Safinamide
- Amitriptyline + Safinamide Contraindicated
- Amoxapine + Safinamide Contraindicated
- Amphetamine polistirex + Safinamide Contraindicated
- Clomipramine + Safinamide Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Desipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Buprenorphine subdermal implant with Safinamide?
MediHelp rates the interaction as major. Buprenorphine subdermal implant and Safinamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Buprenorphine has serotonergic activity and co-use with MAO inhibitors may cause serotonin syndrome or opioid toxicity. Risk is greater at initiation and dose changes.
How serious is the interaction between Buprenorphine subdermal implant and Safinamide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If used, monitor for agitation, tremor, hyperthermia and sedation, and remove the implant and treat if serotonin syndrome occurs.
What other medicines interact with Safinamide?
MediHelp also lists interactions of Safinamide with, for example, Amitriptyline, Amoxapine, Amphetamine polistirex. The full list is on the Safinamide page.
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