Drug interactions
Buprenorphine transdermal + Eribulin
Severity: Moderate
Buprenorphine transdermal and Eribulin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Transdermal buprenorphine has labeling for QT prolongation, and eribulin can also lengthen the QT interval. Using both may increase the risk of torsades de pointes in susceptible patients.
What this interaction means in plain words
Buprenorphine transdermal and Eribulin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic effect on cardiac repolarization (QT prolongation).
What to do
Check baseline ECG and electrolytes and monitor the QTc during co-therapy. Use the lowest effective buprenorphine dose or switch analgesic if the QTc increases markedly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eribulin
Frequently asked questions
Can I take Buprenorphine transdermal with Eribulin?
MediHelp rates the interaction as moderate. Buprenorphine transdermal and Eribulin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Transdermal buprenorphine has labeling for QT prolongation, and eribulin can also lengthen the QT interval. Using both may increase the risk of torsades de pointes in susceptible patients.
How serious is the interaction between Buprenorphine transdermal and Eribulin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and electrolytes and monitor the QTc during co-therapy. Use the lowest effective buprenorphine dose or switch analgesic if the QTc increases markedly.
What other medicines interact with Eribulin?
MediHelp also lists interactions of Eribulin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Eribulin page.
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