Drug interactions
Buprenorphine transdermal + Imipramine
Severity: Moderate
Buprenorphine transdermal and Imipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval and both cause sedation. Together they may increase arrhythmia and respiratory depression risk, though transdermal buprenorphine has relatively modest QT effect at usual doses.
What this interaction means in plain words
Buprenorphine transdermal and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation and CNS depressant effects.
What to do
Monitor ECG in patients with cardiac risk factors and watch for sedation and respiratory depression. Keep potassium and magnesium normal.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Buprenorphine transdermal with Imipramine?
MediHelp rates the interaction as moderate. Buprenorphine transdermal and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval and both cause sedation. Together they may increase arrhythmia and respiratory depression risk, though transdermal buprenorphine has relatively modest QT effect at usual doses.
How serious is the interaction between Buprenorphine transdermal and Imipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG in patients with cardiac risk factors and watch for sedation and respiratory depression. Keep potassium and magnesium normal.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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