Drug interactions
Buprenorphine transdermal + Nilotinib
Severity: Moderate
Buprenorphine transdermal and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QTc interval, raising the risk of ventricular arrhythmias. Nilotinib may also increase buprenorphine exposure, causing greater sedation.
What this interaction means in plain words
Buprenorphine transdermal and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QTc prolongation; CYP3A4 inhibition by nilotinib may raise buprenorphine levels.
What to do
Check a baseline ECG and monitor QTc and electrolytes. Watch for sedation and respiratory depression.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Buprenorphine transdermal with Nilotinib?
MediHelp rates the interaction as moderate. Buprenorphine transdermal and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can prolong the QTc interval, raising the risk of ventricular arrhythmias. Nilotinib may also increase buprenorphine exposure, causing greater sedation.
How serious is the interaction between Buprenorphine transdermal and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and monitor QTc and electrolytes. Watch for sedation and respiratory depression.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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