Drug interactions
Busulfan + Trastuzumab
Severity: Moderate
Busulfan and Trastuzumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Busulfan causes profound myelosuppression, and trastuzumab has been linked to increased neutropenia when added to myelosuppressive chemotherapy. Together they may heighten the risk of serious infection.
What this interaction means in plain words
Busulfan and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Busulfan belongs to Oncology; Trastuzumab belongs to Oncology.
Why it happens
Additive hematologic toxicity; trastuzumab may worsen chemotherapy-induced neutropenia by an incompletely understood mechanism.
What to do
Monitor blood counts closely and for signs of infection, with supportive care such as growth factors or prophylaxis per local protocol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trastuzumab
Other interactions of Busulfan
- Busulfan + Carboplatin Major
- Busulfan + Chlorambucil Major
- Busulfan + Cyclophosphamide Major
- Busulfan + Fingolimod Major
- Busulfan + Hydroxycarbamide Major
- Busulfan + Ifosfamide Major
Frequently asked questions
Can I take Busulfan with Trastuzumab?
MediHelp rates the interaction as moderate. Busulfan and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Busulfan causes profound myelosuppression, and trastuzumab has been linked to increased neutropenia when added to myelosuppressive chemotherapy. Together they may heighten the risk of serious infection.
How serious is the interaction between Busulfan and Trastuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts closely and for signs of infection, with supportive care such as growth factors or prophylaxis per local protocol.
What other medicines interact with Trastuzumab?
MediHelp also lists interactions of Trastuzumab with, for example, Daunorubicin, Doxorubicin liposomal, Doxorubicin. The full list is on the Trastuzumab page.
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