Drug interactions
Butabarbital + Cyclophosphamide
Severity: Moderate
Butabarbital and Cyclophosphamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates induce hepatic enzymes including CYP2B6, which activates cyclophosphamide. Induction may speed formation of active and toxic metabolites, with possible changes in both efficacy and toxicity.
What this interaction means in plain words
Butabarbital and Cyclophosphamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Barbiturate induction of CYP2B6 and other CYP enzymes alters cyclophosphamide bioactivation.
What to do
Monitor for increased myelosuppression and urotoxicity, and consider a non-inducing sedative alternative where possible. Ensure adequate hydration and mesna use according to the regimen.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclophosphamide
Frequently asked questions
Can I take Butabarbital with Cyclophosphamide?
MediHelp rates the interaction as moderate. Butabarbital and Cyclophosphamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates induce hepatic enzymes including CYP2B6, which activates cyclophosphamide. Induction may speed formation of active and toxic metabolites, with possible changes in both efficacy and toxicity.
How serious is the interaction between Butabarbital and Cyclophosphamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased myelosuppression and urotoxicity, and consider a non-inducing sedative alternative where possible. Ensure adequate hydration and mesna use according to the regimen.
What other medicines interact with Cyclophosphamide?
MediHelp also lists interactions of Cyclophosphamide with, for example, Adenovirus types 4 and 7 live, Belatacept, Bendamustine. The full list is on the Cyclophosphamide page.
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