Drug interactions
Butabarbital + Deflazacort
Severity: Major
Butabarbital and Deflazacort: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates induce CYP3A4 and can markedly lower exposure to deflazacort's active metabolite. This may lead to loss of therapeutic effect.
What this interaction means in plain words
Butabarbital and Deflazacort can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Barbiturate induction of CYP3A4 increases deflazacort metabolite clearance.
What to do
Avoid combination, as labeling advises against moderate or strong CYP3A4 inducers. Use a non-inducing sedative alternative.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Butabarbital with Deflazacort?
MediHelp rates the interaction as major. Butabarbital and Deflazacort can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Barbiturates induce CYP3A4 and can markedly lower exposure to deflazacort's active metabolite. This may lead to loss of therapeutic effect.
How serious is the interaction between Butabarbital and Deflazacort?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combination, as labeling advises against moderate or strong CYP3A4 inducers. Use a non-inducing sedative alternative.
What other medicines interact with Deflazacort?
MediHelp also lists interactions of Deflazacort with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Deflazacort page.
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