Drug interactions
Butabarbital + Dimenhydrinate
Severity: Moderate
Butabarbital and Dimenhydrinate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates are potent CNS depressants, and a sedating antihistamine will increase drowsiness and impair coordination. Excessive combined depression may affect breathing, especially at high doses or with alcohol.
What this interaction means in plain words
Butabarbital and Dimenhydrinate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression via GABA-A potentiation and H1 antagonism.
What to do
Avoid combined use where possible; if needed, lower doses and monitor sedation and respiratory status. Warn against alcohol and driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dimenhydrinate
Frequently asked questions
Can I take Butabarbital with Dimenhydrinate?
MediHelp rates the interaction as moderate. Butabarbital and Dimenhydrinate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates are potent CNS depressants, and a sedating antihistamine will increase drowsiness and impair coordination. Excessive combined depression may affect breathing, especially at high doses or with alcohol.
How serious is the interaction between Butabarbital and Dimenhydrinate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combined use where possible; if needed, lower doses and monitor sedation and respiratory status. Warn against alcohol and driving.
What other medicines interact with Dimenhydrinate?
MediHelp also lists interactions of Dimenhydrinate with, for example, Belladonna and opium, Brexanolone, Calcium / magnesium / potassium / sodium oxybates. The full list is on the Dimenhydrinate page.
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