Drug interactions
Butabarbital + Doxylamine
Severity: Moderate
Butabarbital and Doxylamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butabarbital is a barbiturate sedative-hypnotic and doxylamine is a sedating antihistamine. Together they can cause excessive drowsiness, impaired psychomotor performance and respiratory depression.
What this interaction means in plain words
Butabarbital and Doxylamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression via GABA-A potentiation and central H1 receptor blockade.
What to do
Avoid combining for sleep; if both are needed use reduced doses and monitor sedation and respiratory status. Counsel against driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxylamine
Frequently asked questions
Can I take Butabarbital with Doxylamine?
MediHelp rates the interaction as moderate. Butabarbital and Doxylamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Butabarbital is a barbiturate sedative-hypnotic and doxylamine is a sedating antihistamine. Together they can cause excessive drowsiness, impaired psychomotor performance and respiratory depression.
How serious is the interaction between Butabarbital and Doxylamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining for sleep; if both are needed use reduced doses and monitor sedation and respiratory status. Counsel against driving.
What other medicines interact with Doxylamine?
MediHelp also lists interactions of Doxylamine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Doxylamine page.
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