Drug interactions
Butabarbital + Flurbiprofen
Severity: Minor
Butabarbital and Flurbiprofen: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butabarbital may lower flurbiprofen exposure through enzyme induction. The reduction is expected to be modest and could slightly weaken analgesic or anti-inflammatory effect.
What this interaction means in plain words
Butabarbital and Flurbiprofen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Barbiturate-mediated induction of hepatic CYP2C9 may increase flurbiprofen metabolism.
What to do
No routine change is needed; if pain control worsens during long-term barbiturate use, reassess the flurbiprofen dose or consider an alternative analgesic.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Frequently asked questions
Can I take Butabarbital with Flurbiprofen?
MediHelp rates the interaction as minor. Butabarbital and Flurbiprofen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Butabarbital may lower flurbiprofen exposure through enzyme induction. The reduction is expected to be modest and could slightly weaken analgesic or anti-inflammatory effect.
How serious is the interaction between Butabarbital and Flurbiprofen?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; if pain control worsens during long-term barbiturate use, reassess the flurbiprofen dose or consider an alternative analgesic.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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