Drug interactions
Butabarbital + Frovatriptan
Severity: Minor
Butabarbital and Frovatriptan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates induce hepatic enzymes and may lower frovatriptan exposure, although CYP1A2 is only one of its clearance routes. A meaningful loss of migraine efficacy is unlikely but possible.
What this interaction means in plain words
Butabarbital and Frovatriptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Barbiturate-mediated induction of CYP1A2 may increase frovatriptan metabolism.
What to do
No dose change is normally needed. Reassess response if frovatriptan seems less effective during long-term barbiturate use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Frovatriptan
- Almotriptan + Frovatriptan Contraindicated
- Dihydroergotamine intranasal + Frovatriptan Contraindicated
- Dihydroergotamine + Frovatriptan Contraindicated
- Eletriptan + Frovatriptan Contraindicated
- Ergoloid mesylates + Frovatriptan Contraindicated
- Ergotamine + Frovatriptan Contraindicated
Frequently asked questions
Can I take Butabarbital with Frovatriptan?
MediHelp rates the interaction as minor. Butabarbital and Frovatriptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Barbiturates induce hepatic enzymes and may lower frovatriptan exposure, although CYP1A2 is only one of its clearance routes. A meaningful loss of migraine efficacy is unlikely but possible.
How serious is the interaction between Butabarbital and Frovatriptan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is normally needed. Reassess response if frovatriptan seems less effective during long-term barbiturate use.
What other medicines interact with Frovatriptan?
MediHelp also lists interactions of Frovatriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Frovatriptan page.
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