Drug interactions
Butabarbital + Ibuprofen
Severity: Minor
Butabarbital and Ibuprofen: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates induce hepatic enzymes, including CYP2C9 which metabolizes ibuprofen. Ibuprofen exposure may be reduced, though the clinical effect is probably small and can be offset by dose titration.
What this interaction means in plain words
Butabarbital and Ibuprofen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Barbiturate induction of CYP2C enzymes increases ibuprofen metabolism.
What to do
No routine adjustment is needed; reassess analgesic response and increase ibuprofen dose within labeled limits if effect is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Frequently asked questions
Can I take Butabarbital with Ibuprofen?
MediHelp rates the interaction as minor. Butabarbital and Ibuprofen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Barbiturates induce hepatic enzymes, including CYP2C9 which metabolizes ibuprofen. Ibuprofen exposure may be reduced, though the clinical effect is probably small and can be offset by dose titration.
How serious is the interaction between Butabarbital and Ibuprofen?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; reassess analgesic response and increase ibuprofen dose within labeled limits if effect is inadequate.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
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