Drug interactions
Butabarbital + Ifosfamide
Severity: Moderate
Butabarbital and Ifosfamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates induce CYP2B6 and CYP3A4, which can speed ifosfamide conversion both to active alkylating metabolites and to neurotoxic chloroacetaldehyde. This may increase toxicity, including encephalopathy and nephrotoxicity, and the sedative effect of the barbiturate may also confuse the assessment of neurotoxicity.
What this interaction means in plain words
Butabarbital and Ifosfamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of CYP2B6 and CYP3A4 by butabarbital increases ifosfamide bioactivation and toxic metabolite formation.
What to do
Prefer a non-inducing alternative where possible. If combined, monitor for neurotoxicity, renal function and myelosuppression and adjust the ifosfamide dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Frequently asked questions
Can I take Butabarbital with Ifosfamide?
MediHelp rates the interaction as moderate. Butabarbital and Ifosfamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates induce CYP2B6 and CYP3A4, which can speed ifosfamide conversion both to active alkylating metabolites and to neurotoxic chloroacetaldehyde. This may increase toxicity, including encephalopathy and nephrotoxicity, and the sedative effect of the barbiturate may also confuse the assessment of neurotoxicity.
How serious is the interaction between Butabarbital and Ifosfamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-inducing alternative where possible. If combined, monitor for neurotoxicity, renal function and myelosuppression and adjust the ifosfamide dose as needed.
What other medicines interact with Ifosfamide?
MediHelp also lists interactions of Ifosfamide with, for example, Adenovirus types 4 and 7 live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Ifosfamide page.
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