Drug interactions
Butabarbital + Lidocaine
Severity: Minor
Butabarbital and Lidocaine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates induce hepatic enzymes, which can accelerate lidocaine metabolism and lower its concentrations. This may reduce antiarrhythmic or anesthetic effect, though the magnitude is variable.
What this interaction means in plain words
Butabarbital and Lidocaine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Barbiturate-mediated induction of hepatic CYP enzymes increasing lidocaine clearance.
What to do
Monitor lidocaine response, and serum concentrations if used as an infusion for arrhythmia; increase dose only if effect is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lidocaine
- Bupivacaine liposome + Lidocaine Major
- Disopyramide + Lidocaine Major
- Ex vivo expanded autologous human corneal epithelial cells containing stem cells + Lidocaine Major
- Lidocaine + Nirmatrelvir / ritonavir Major
- Lidocaine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Lidocaine + Pimozide Major
Frequently asked questions
Can I take Butabarbital with Lidocaine?
MediHelp rates the interaction as minor. Butabarbital and Lidocaine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Barbiturates induce hepatic enzymes, which can accelerate lidocaine metabolism and lower its concentrations. This may reduce antiarrhythmic or anesthetic effect, though the magnitude is variable.
How serious is the interaction between Butabarbital and Lidocaine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor lidocaine response, and serum concentrations if used as an infusion for arrhythmia; increase dose only if effect is inadequate.
What other medicines interact with Lidocaine?
MediHelp also lists interactions of Lidocaine with, for example, Bupivacaine liposome, Disopyramide, Ex vivo expanded autologous human corneal epithelial cells containing stem cells. The full list is on the Lidocaine page.
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