Drug interactions
Butabarbital + Lofexidine
Severity: Moderate
Butabarbital and Lofexidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates cause marked CNS depression, which adds to lofexidine sedation and hypotension. Excessive drowsiness and impaired psychomotor function are possible.
What this interaction means in plain words
Butabarbital and Lofexidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression.
What to do
Monitor sedation and blood pressure, reduce doses as needed, and warn patients against driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Frequently asked questions
Can I take Butabarbital with Lofexidine?
MediHelp rates the interaction as moderate. Butabarbital and Lofexidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates cause marked CNS depression, which adds to lofexidine sedation and hypotension. Excessive drowsiness and impaired psychomotor function are possible.
How serious is the interaction between Butabarbital and Lofexidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and blood pressure, reduce doses as needed, and warn patients against driving.
What other medicines interact with Lofexidine?
MediHelp also lists interactions of Lofexidine with, for example, Adagrasib, Alfuzosin, Amiodarone. The full list is on the Lofexidine page.
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