Drug interactions
Butabarbital + Metformin-repaglinide
Severity: Moderate
Butabarbital and Metformin-repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates induce CYP3A4 and CYP2C8, enzymes that metabolize repaglinide. Repaglinide exposure may fall, reducing glycemic control.
What this interaction means in plain words
Butabarbital and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Barbiturate-mediated induction of CYP3A4 and CYP2C8 increases repaglinide clearance.
What to do
Monitor blood glucose and increase the repaglinide dose if needed; reduce it again if the barbiturate is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Frequently asked questions
Can I take Butabarbital with Metformin-repaglinide?
MediHelp rates the interaction as moderate. Butabarbital and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates induce CYP3A4 and CYP2C8, enzymes that metabolize repaglinide. Repaglinide exposure may fall, reducing glycemic control.
How serious is the interaction between Butabarbital and Metformin-repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and increase the repaglinide dose if needed; reduce it again if the barbiturate is stopped.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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