Drug interactions
Butabarbital + Prednisolone
Severity: Moderate
Butabarbital and Prednisolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates induce hepatic enzymes and can speed prednisolone clearance, weakening its effect. Loss of disease control may occur, especially in patients relying on the steroid for adrenal replacement or serious inflammatory disease.
What this interaction means in plain words
Butabarbital and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Barbiturate induction of CYP3A4 and other hepatic enzymes increases corticosteroid metabolism.
What to do
Monitor clinical response and increase the prednisolone dose if effect is lost. Re-evaluate the dose when the barbiturate is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisolone
- Bcg vaccine live + Prednisolone Contraindicated
- Measles mumps and rubella vaccine live + Prednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Prednisolone Contraindicated
- Measles vaccine + Prednisolone Contraindicated
- Mifepristone + Prednisolone Contraindicated
- Prednisolone + Radium-223 dichloride Contraindicated
Frequently asked questions
Can I take Butabarbital with Prednisolone?
MediHelp rates the interaction as moderate. Butabarbital and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates induce hepatic enzymes and can speed prednisolone clearance, weakening its effect. Loss of disease control may occur, especially in patients relying on the steroid for adrenal replacement or serious inflammatory disease.
How serious is the interaction between Butabarbital and Prednisolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and increase the prednisolone dose if effect is lost. Re-evaluate the dose when the barbiturate is stopped.
What other medicines interact with Prednisolone?
MediHelp also lists interactions of Prednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Prednisolone page.
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