Drug interactions
Butabarbital + Repaglinide
Severity: Moderate
Butabarbital and Repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butabarbital is a barbiturate that induces hepatic enzymes, including CYP3A4. It may lower repaglinide exposure and weaken glycemic control.
What this interaction means in plain words
Butabarbital and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Barbiturate induction of CYP3A4 (and CYP2C8) increases repaglinide metabolism.
What to do
Monitor blood glucose when butabarbital is started or stopped. Increase the repaglinide dose if needed, and lower it again when the inducer is withdrawn.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporin + Repaglinide Major
- Deferasirox + Repaglinide Major
Frequently asked questions
Can I take Butabarbital with Repaglinide?
MediHelp rates the interaction as moderate. Butabarbital and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Butabarbital is a barbiturate that induces hepatic enzymes, including CYP3A4. It may lower repaglinide exposure and weaken glycemic control.
How serious is the interaction between Butabarbital and Repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when butabarbital is started or stopped. Increase the repaglinide dose if needed, and lower it again when the inducer is withdrawn.
What other medicines interact with Repaglinide?
MediHelp also lists interactions of Repaglinide with, for example, Gemfibrozil, Clarithromycin, Clopidogrel. The full list is on the Repaglinide page.
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