Drug interactions
Butabarbital + Selegiline
Severity: Minor
Butabarbital and Selegiline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
A theoretical interaction in which selegiline might increase butabarbital exposure and sedation. No clinically meaningful effect is established.
What this interaction means in plain words
Butabarbital and Selegiline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible reduced barbiturate metabolism; the mechanism is not established.
What to do
No routine action needed. Monitor for excess sedation when starting the combination.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Frequently asked questions
Can I take Butabarbital with Selegiline?
MediHelp rates the interaction as minor. Butabarbital and Selegiline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. A theoretical interaction in which selegiline might increase butabarbital exposure and sedation. No clinically meaningful effect is established.
How serious is the interaction between Butabarbital and Selegiline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action needed. Monitor for excess sedation when starting the combination.
What other medicines interact with Selegiline?
MediHelp also lists interactions of Selegiline with, for example, Amitriptyline, Amoxapine, Atomoxetine. The full list is on the Selegiline page.
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