Drug reference
selegiline
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Central Nervous System (Anti Parkinsonian Drugs)
Mechanism of action
Selective MAO-B inhibitor; may increase dopaminergic activity by interfering with dopamine reuptake at the synapse.
Common side effects
- Arrhythmias
- Dry mouth
- Nausea
- Dyskinesia
- Abdominal pain
Known interactions (31)
- amitriptyline + selegiline Contraindicated
- atomoxetine + selegiline Contraindicated
- brimonidine + selegiline Contraindicated
- bupropion + selegiline Contraindicated
- bupropion-naltrexone + selegiline Contraindicated
- buspirone + selegiline Contraindicated
- carbamazepine + selegiline Contraindicated
- citalopram + selegiline Contraindicated
- clomipramine + selegiline Contraindicated
- desipramine + selegiline Contraindicated
- desvenlafaxine + selegiline Contraindicated
- dextroamphetamine + selegiline Contraindicated
- dextromethorphan + selegiline Contraindicated
- duloxetine + selegiline Contraindicated
- escitalopram + selegiline Contraindicated
- fluoxetine + selegiline Contraindicated
- fluvoxamine + selegiline Contraindicated
- imipramine + selegiline Contraindicated
- isocarboxazid + selegiline Contraindicated
- selegiline + sertraline Contraindicated
- selegiline + xylometazoline Contraindicated
- cyproheptadine + selegiline Major
- dobutamine + selegiline Major
- dopamine + selegiline Major
- epinephrine + selegiline Major
- fentanyl + selegiline Major
- armodafinil + selegiline Moderate
- caffeine + selegiline Moderate
- carbidopa-entacapone-levodopa + selegiline Moderate
- carbidopa-levodopa + selegiline Moderate
- isoproterenol + selegiline Moderate
Related conditions
Frequently asked questions
What drug class is selegiline?
selegiline belongs to: Central Nervous System.
How does selegiline work?
Selective MAO-B inhibitor; may increase dopaminergic activity by interfering with dopamine reuptake at the synapse.
What are the common side effects of selegiline?
Arrhythmias, Dry mouth, Nausea, Dyskinesia, Abdominal pain
Which drugs interact with selegiline?
amitriptyline, atomoxetine, brimonidine, bupropion, bupropion-naltrexone, buspirone, carbamazepine, citalopram, clomipramine, desipramine, desvenlafaxine, dextroamphetamine, dextromethorphan, duloxetine, escitalopram
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