Drug interactions
Butabarbital + Sorafenib
Severity: Moderate
Butabarbital and Sorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates are enzyme inducers and may lower sorafenib concentrations. Reduced exposure could lessen antitumor efficacy.
What this interaction means in plain words
Butabarbital and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Butabarbital induces CYP3A4 and possibly UGT1A9, increasing sorafenib metabolism.
What to do
Where possible, use a non-inducing sedative or hypnotic. If the combination is needed, monitor for loss of tumor response and consider whether a sorafenib dose adjustment is warranted.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sorafenib
Frequently asked questions
Can I take Butabarbital with Sorafenib?
MediHelp rates the interaction as moderate. Butabarbital and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates are enzyme inducers and may lower sorafenib concentrations. Reduced exposure could lessen antitumor efficacy.
How serious is the interaction between Butabarbital and Sorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible, use a non-inducing sedative or hypnotic. If the combination is needed, monitor for loss of tumor response and consider whether a sorafenib dose adjustment is warranted.
What other medicines interact with Sorafenib?
MediHelp also lists interactions of Sorafenib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sorafenib page.
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