Drug interactions
Butabarbital + Tamoxifen
Severity: Moderate
Butabarbital and Tamoxifen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butabarbital, a barbiturate, induces hepatic enzymes and can increase tamoxifen clearance. Exposure to tamoxifen and its metabolites may fall, potentially reducing anti-estrogen efficacy.
What this interaction means in plain words
Butabarbital and Tamoxifen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Barbiturate induction of CYP3A4 and CYP2C9 increases tamoxifen metabolism.
What to do
Avoid long-term combination where possible and consider a non-inducing sedative. If unavoidable, monitor clinical response to tamoxifen.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tamoxifen
- Amiodarone + Tamoxifen Major
- Anastrozole + Tamoxifen Major
- Bupropion + Tamoxifen Major
- Carbamazepine + Tamoxifen Major
- Cinacalcet + Tamoxifen Major
- Dacomitinib + Tamoxifen Major
Frequently asked questions
Can I take Butabarbital with Tamoxifen?
MediHelp rates the interaction as moderate. Butabarbital and Tamoxifen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Butabarbital, a barbiturate, induces hepatic enzymes and can increase tamoxifen clearance. Exposure to tamoxifen and its metabolites may fall, potentially reducing anti-estrogen efficacy.
How serious is the interaction between Butabarbital and Tamoxifen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid long-term combination where possible and consider a non-inducing sedative. If unavoidable, monitor clinical response to tamoxifen.
What other medicines interact with Tamoxifen?
MediHelp also lists interactions of Tamoxifen with, for example, Amiodarone, Anastrozole, Bupropion. The full list is on the Tamoxifen page.
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