Drug interactions
Butabarbital + Timolol
Severity: Moderate
Butabarbital and Timolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates induce hepatic enzymes and can reduce plasma levels of beta-blockers that undergo hepatic metabolism, such as timolol. This may diminish heart rate and blood pressure control.
What this interaction means in plain words
Butabarbital and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Barbiturate induction of hepatic CYP enzymes increases timolol clearance.
What to do
Monitor heart rate and blood pressure and increase the timolol dose if response is lost. Reassess the dose when the barbiturate is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Timolol
- Acebutolol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
- Atenolol-chlorthalidone + Timolol Major
Frequently asked questions
Can I take Butabarbital with Timolol?
MediHelp rates the interaction as moderate. Butabarbital and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates induce hepatic enzymes and can reduce plasma levels of beta-blockers that undergo hepatic metabolism, such as timolol. This may diminish heart rate and blood pressure control.
How serious is the interaction between Butabarbital and Timolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure and increase the timolol dose if response is lost. Reassess the dose when the barbiturate is stopped.
What other medicines interact with Timolol?
MediHelp also lists interactions of Timolol with, for example, Acebutolol, Aldesleukin, Amifostine. The full list is on the Timolol page.
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